Researchers develop innovative technique for distinguishing tumor from normal tissue

The team evaluated the new imaging technology, known as fluorescence lifetime imaging, using specimens from more than 60 patients that underwent surgery of various cancers. The team reported that the technique was over 97 percent accurate across tumor types, with the potential to improve the accuracy of cancer surgeries.Removing a patient's tumor while sparing healthy tissue requires exquisite precision, but often surgeons must rely on their eyes and hands to determine where to cut.

"This technology has taken us to the brink of a revolution in solid tumor surgery," said Mark Varvares, MD, chief of Otolaryngology-Head and Neck Surgery at Mass Eye and Ear.

The technique used by Kumar and colleagues, known as FLT imaging, takes a different tact. Instead of relying on dyes only for targeting cancer, the technique uses high-speed cameras to detect changes in the property of the light emitted by tissue. In previous studies in preclinical models, Kumar and colleagues found that tumors in mice injected with a dye known as indocyanine green had a longer fluorescence lifetime compared to normal tissue.

"Our work suggests that the combination of fluorescence lifetime imaging with ICG could improve surgical resections, thereby impacting patient lives," said Kumar."We're excited to take these next steps to move our discoveries closer to clinical impact."Rahul Pal, Thinzar M. Lwin, Murali Krishnamoorthy, Hannah R. Collins, Corey D. Chan, Andrey Prilutskiy, MacLean P. Nasrallah, Tom H. Dijkhuis, Shriya Shukla, Amy L. Kendall, Michael S. Marshall, Stefan A. Carp, Yin P.

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