elsewhere in the body. The researchers compare this highly regulated process to a"controlled demolition."
But when heparanase is functioning abnormally, it starts rapidly degrading heparan sulfate, which can lead to the increased spread of viral or cancer cells that are being liberated from the cellular structure.But finding a molecule to do this safely has proven difficult, explained Tejabhiram Yadavalli, a research assistant professor in ophthalmology and visual sciences at UIC and co-first author on the study. The other primary author, Pradeep Chopra, is from the University of Georgia.
For one thing, heparanase plays a key role in the pro-survival activity of the cell, so inhibiting it can lead to toxicity. The molecule this team of researchers identified proved to be non-toxic when tested on cells, Yadavalli said. Additionally, heparanase inhibitors are often a form of the drug heparin, which is an anticoagulant. The team used a heparin-based molecule in their study but were able to remove its anticoagulant properties, so it was safe to use in that respect.
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