Research seeks to develop mRNA lipid nanoparticles for next-generation oral cancer tumor suppressor therapy

Research seeks to develop mRNA lipid nanoparticles for next-generation oral cancer tumor suppressor therapyA study aiming to develop a lipid nanoparticles platform for treating oral squamous cell carcinoma utilizing p53 mRNA was presented at the 102nd General Session of the, which was held in conjunction with the 53rd Annual Meeting of the American Association for Dental, Oral, and Craniofacial Research and the 48th Annual Meeting of the Canadian Association for Dental Research, on March 13-16,...

The study, by Marshall Scott Padilla of University of Pennsylvania, Philadelphia, U.S., formulated a library of LNPs with luciferase mRNA and tested in CAL-27 cells, a model OSCC line. The LNPs were also injected intravenously into C57BL/6 mice to examine their propensity for off-target liver transfection. The LNPs that had high luminescence in CAL-27 cells and low liver transfection progressed to the next round of screening.

After two rounds of screening, the LNP E10i-494 demonstrated immense mRNA transfection in vitro and in two murine tumor models. Additionally, the LNP had low levels of liver transfection, showcasing a promising safety profile. In the orthotopic model, the LNP successfully entered and transfected lymph nodes, which is essential for preventing tumor metastasis. E10i-494 also demonstrated potent cell killing after being reformulated with p53 mRNA.

Source: Healthcare Press (healthcarepress.net)

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