Recent research suggests that long term benzodiazepine use may increase dementia risk.

A recent study revealed the mechanism by which benzos interfere with plasticity and cognitive abilities.

Another study compared over 70,000 non-institutionalized Finnish men and women diagnosed with dementia from 2005-2010 with a larger demographic-matched group without dementia . The researchers concluded that individuals taking benzodiazepines and related drugs had a slightly increased risk of developing dementia.

In September 2020, the FDA announced that they would update the"black box warning" for benzodiazepines to include information about the risks of physical dependence, withdrawal reactions, misuse, abuse, and addiction . This was in addition to a previous warning about the risks of taking benzodiazepines concurrently with opiates, which could lead to death .

The researchers used a unique lab model called “Guwiyang Wurra-TSPO knockout,” a healthy mouse lacking a protein present in the mitochondrion, the cell’s energy-providing organelle . Anti-anxiety drugs like diazepam bind to TSPO on the surface of microglial cell organelles. Microglial cells are the brain’s first immune responders and are implicated in dementia,In animal models without TSPO, the physiological impairments associated with cognitive impairment from diazepam use were not observed.

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