"We found that the novel protein nanoparticles combined with the adjuvants could induce significantly improved mucosal immune responses and the accumulation of lung resident memory cells in the local respiratory tracts, providing complete protection against influenza viral infections," said Dr. Wandi Zhu, first author of the study and a research assistant professor in the Institute for Biomedical Sciences at Georgia State.
Influenza A virus is one of the most threatening respiratory pathogens and can cause severe morbidity, mortality and heavy economic burdens, especially in flu epidemics or pandemics. While vaccination is effective in preventing or reducing viral infections during annual flu seasons, the selection of vaccine strains depends on circulating viral surveillance and prediction.
Mismatched strains could significantly impair vaccine efficiency. Also, the production of the current quadrivalent influenza vaccine is time-consuming. New vaccine technologies are needed to easily manufacture a universal influenza vaccine. The researchers have focused their work on developing different types of protein nanoparticle vaccines against both influenza A and influenza B
Source: Education Headlines (educationheadlines.net)
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