Distribution of demographic data for patients with and without reported outcomes. Maternal age. Dotted vertical line shows advanced maternal age threshold of 35 years. Gestational age. Fetal fraction. Traces indicate gaussian kernel‐smoothed data for clarity.Results shown are based on patient results reanalyzed using the updated algorithm.Overall test performance combining all three aneuploidies was reanalyzed assuming different outcome response rates for FNs and FPs, as indicated below.
Supplementary Table S4: Evaluation of uncertainty of inferred test performance for low‐FF samples due to low sample size. Simulated confidence intervals for low‐FF inferred sensitivity and inferred specificity due to the relatively small sample size of positives at low FF, as described in Supplementary Text S2. The confidence intervals of inferred sensitivity and inferred specificity at low FF are comparable to the uncertainty ranges reported in Table 2. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors.