separated its 4060 patients with AF into normal , overweight , and obese categories, per the convention at the time. It concluded that"obese patients with atrial fibrillation appear to have better long-term outcomes than nonobese patients."Also noteworthy in the current analysis, variation in BMI didn't seem to affect mortality or risk for major bleeding or nonhemorrhagicaccording to choice of oral anticoagulant — whether a new oral anticoagulant or a vitamin-K antagonist .
Indeed, the report notes, use of NOACs compared with VKA was associated with a 23% drop in risk for death among patients who were either normal-weight or overweight and also in those who were obese or extremely obese. Whereas the benefits of NOACs compared to VKA seem similar for patients with a BMI of 30 or 34 compared with a BMI of 23, for example,"none of the studies have many people with 50 BMI." Many clinicians"feel uncomfortable giving the same dose of NOAC to somebody who has a 60 BMI," he said. At least with warfarin,"you can check the INR [international normalized ratio]."
Source: Healthcare Press (healthcarepress.net)
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