Noninvasive transcranial alternating current stimulation may lead to rapid improvement in major depressive disorder , results of a randomized, sham-controlled trial suggested. However, independent experts said more research is needed to confirm its benefit. severity, post hoc analyses showed active tACS was superior to sham in women and in those with high adherence to treatment.
Both treatment groups showed similar clinically significant improvements in mean BDI-II scores at week 2 compared with baseline , with no significant difference between groups approval. Reached for comment, Roger McIntyre, MD, professor of psychiatry and pharmacology, University of Toronto, Toronto, Canada, and head of the Mood Disorders Psychopharmacology Unit, said the efficacy being reported with tACS is"promising but needs to be replicated in a much larger study.
Flavio Frohlich, PhD, professor, Department of Psychiatry, University of North Carolina at Chapel Hill and director of the Carolina Center for Neurostimulation, also emphasized the need for more study.
Major Depressive Disorder Unipolar Depression Clinical Depression MDD Brain Stimulation Depression Brain Adherence Adherence To Medication Issues For Patients Compliance Drug Compliance Treatment Adherence Adverse Effects Side Effects North Carolina Patient Safety Canada Canadian Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial
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