Immunotherapy plus chemotherapy — the standard treatment for non–small cell lung cancer — does not confer survival benefits over immunotherapy alone but does increase the side-effect burden in older patients.Clinical trials have shown that combining immunotherapy and chemotherapy leads to longer overall survival in patients with NSCLC, but these trials often excluded older patients.
Programmed death ligand-1 expression < 1%, 1%-49%, and ≥ 50% was noted in 22%, 31%, and 33% of tumors, respectively. PD-L1 expression was unknown in 14% of tumors. Compared with immunotherapy alone, immunotherapy plus chemotherapy did not improve overall survival or progression-free survival in patients grouped by PD-L1 expression.
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