NFL Week 5 Preview: Best Games, Best Bets, Predictions

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Our experts have ATS and over/under picks for the five biggest games of the week, including the Cowboys-49ers showdown on Sunday night.

him of his lackluster performance during the postseason loss to the 49ers that ended the Cowboys’ 2022 season. But don’t worry, Dak. We only look forward here. is without a doubt the best game on the Week 5 NFL schedule. This game, however, lost a little sizzle after the Cowboys fell to the Cardinals in Week 3. Oh, wait, gotta look forward.

The 49ers stomped out Arizona, 35–16, behind McCaffrey’s four-touchdown day for their 14th straight regular-season win. Deebo Samuel and George Kittle were hardly involved on offense and it didn't even matter — the bulk of Brock Purdy’s passing attempts went to Brandon Aiyuk and McCaffrey, who combined for over 300 total yards.

The Eagles are one of two remaining unbeaten teams, but they’ve hardly been dominant. All but one of their wins have been decided by six points or fewer and their defense has regressed due to injuries and offseason departures. The offense is still one of the league’s best as it ranks fifth in points per game and second in rushing yards. D’Andre Swift has been a revelation for the running game but Jalen Hurts has yet to return to MVP-level play.

The last time these teams met was in 2021 when the Jaguars, who went on to have the No. 1 pick that year, beat a playoff-bound Bills team, 9–6. Buffalo’s offense has drawn plenty of attention, but its defense ranks second in points allowed per game . That edge might end up deciding this game.Pittsburgh has dominated Baltimore in recent series history, having won five of the last six games. Of course, Lamar Jackson was only active for two of those and he hasn’t beat the Steelers since 2019.

 

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