The case, reported by infectious disease specialists at the Amsterdam University Medical Center in The Netherlands, describes a now-deceased 72-year-old immunocompromised man who had COVID-19 for 613 days – so long theThe man had received multiple COVID-19 vaccinations but his immune system had failed to mount a sufficiently protective response against the virus, which often happens in older people and immunocompromised individuals.
As this case shows, immune systems weakened by illness or suppressed by treatment also struggle to clear existing infections. The man previously had ainfection in this described case is extreme, but prolonged infections in immunocompromised patients are much more common compared to the general community," Amsterdam University Medical Center medical student Magda Vergouwe and colleagues
Routine genomic surveillance revealed the man was initially infected in February 2022 with the Omicron BA.1.17 variant. But within weeks of treatment, the virus mutated to become resistant toAll told, genomic sequencing of 27 nasal and throat swabs collected between February 2022 and September 2023 showed the man's virus had accumulated an extra 50 mutations compared to Omicron BA.1 variants circulating at the time.
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