Receive email when new articles are published onA simple prediction model developed with US and European cohorts shows accuracy in identifying patients with relapsed/refractory multiple myeloma who are or are not at high risk for relapsing after treatment with anti–B-cell maturation antigen chimeric antigen receptor T therapy.
Of the patients, 171 were infused with ide-cel, 38 with cilta-cel, and 60 with an academic CAR-T therapy. The patients had a median age of 63, and extramedullary disease was more common in the US cohort vs European in the European cohort vs US negativity rate at any time was 29% and 37%, respectively, and rates of complete response at day 30 were 29% and 26%, respectively.
"Clinically, my hope that this will help us tailor post–CAR-T interventions according to each patient's risk profile," he said. "Exhausted T-cells at collection mean exhausted CAR T-cells at infusion, and so the negative prognostic significance of elevated ferritin — which we don't always check before CAR-T — makes sense."
"Caveats include that factors beyond the baseline features can further influence outcomes," Dr Banerjee noted.
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