Spanish researchers discovered that mice fed a high-fat diet developed significant markers for Alzheimer’s disease. It’s another piece of evidence that following a low-fat, healthy diet benefits not only our physical health, but our cognitive function as well.According to Brain Tomorrow, the study mice were divided into two groups: normal mice and those that were genetically programmed to develop Alzheimer’s disease, the most common form of dementia.
But the researchers also noted that the fat mice had altered levels of miRNAs, which are small RNA molecules that regulate gene expression. A particular miRNA called miR-19a-3p was higher in the blood, cortex, and hippocampus of the Alzheimer’s mice. The hippocampus is a key area in the brain associated with memory.
Other miRNAs were also elevated in both groups of mice fed a high-fat diet. These included miRNAs associated with insulin resistance, inflammation, and the formation of the toxic protein clumps found in the brains of Alzheimer’s patients. This information could mean that a high-fat diet accelerates or worsens Alzheimer’s disease and identifies molecules that could be used to detect the disease.
The study not only provides new data on how a high-fat diet can affect brain health, but also opens the door to future research into dietary strategies to help treat Alzheimer’s disease. It also highlights the importance of a balanced diet in preventing neurodegenerative diseases and identifies miRNAs as targets for therapeutic interventions.
Source: Healthcare Press (healthcarepress.net)
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