Women seem to be dominating the headlines recently, with the triumphant U.S. women’s team World Cup Soccer win and the focus of attention on Capitol Hill’s female legislators. However, one area where women are leading is not a reason for applause: the disproportionate impact of Alzheimer’s disease on the female population.
In one study, the Vanderbilt researchers focused on tau structures in positron emission tomography scans from 301 healthy men and women, as well as 101 men and 60 women with mild cognitive impairment . They found the women with MCI had more tau network connectivity and accelerated spread of tau across more brain regions compared to men.
The study looked at different stages of the disease along with verbal testing scores. In addition to scoring higher on verbal memory, women were found to metabolize glucose more efficiently, which may give women the ability to compensate for dementia damage and retain cognitive function longer. The rate of memory decline for women age 60 to 70 who were married mothers and who never worked was 61% faster compared to their married mother peers who continued to work. Also, moms who had a prolonged period of single motherhood without employment had memory declines 83% faster. Researchers believe the consistent cognitive stimulation from work helps increase cognitive reserve in women.
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