A new genetic variant in individuals who are APOE4 carriers is linked to a 70% reduction in the risk for) gene, which expresses fibronectin, an adhesive glycoprotein that lines the blood vessels at the blood-brain barrier and controls substances that move in and out of the brain.
"Alzheimer's disease may get started with amyloid deposits in the brain, but the disease manifestations are the result of changes that happen after the deposits appear," Caghan Kizil, PhD, of Columbia University Vagelos College of Physicians and Surgeons in New York City, and a co-leader of the study, said in aTo find potentially protective AD variants, the investigators sequenced the genomes of more than 3500 APOE4 carriers older than 70 years with and without AD from various...
Source: Healthcare Press (healthcarepress.net)
Alzheimer Disease Genomics Genomic Medicine Genetics Blood-Brain Barrier BBB - Blood Brain Barrier Brain Blood Blood Vessels Europe European New York Washington
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