New and Improved Option for Detecting Neurologic Pathogens?

, and other neurologic infections is more sensitive than are conventional diagnostics and could vastly improve diagnostic capabilities in the clinic, results of a real-world analysis show.

"Our results justify incorporation of CSF mNGS testing as part of the routine diagnostic workup in hospitalized patients who present with potential central nervous system infections," study investigator Charles Chiu, MD, PhD, professor in the Department of Laboratory Medicine as well as Medicine and Department of Medicine - Infectious Diseases and director of the Clinical Microbiology Laboratory, University of California San Fransisco , said at a press conference.

CSF is"very limiting," Chiu noted."We are unable, practically, from a volume perspective, as well as a cost and turnaround time perspective, to be able to send off every possible test for every possible organism." Overall, the test detected at least one pathogen in 16.6% of cases. More than 70% were DNA or RNA viruses, followed by bacteria, fungi, and parasites. Investigators also conducted a chart review on a subset of 1052 patients at UCSF to compare the performance of CSF nMGS testing with commonly used in-hospital diagnostic tests.

This suggests that mNGS could potentially"detect the hundreds of different pathogens that cause clinically indistinguishable infections," Chui said. Researchers are now evaluating medical charts of the same subcohort of patients to determine whether the test made a clinical difference.

Meningococcal Disease Meningitis CSF Cerebrospinal Fluid Central Nervous System Infection Cns Infection Tropical Infection Tropical Disease Practice Management Revenue Encephalitis Meningitis Vasculitis Vasculitides Angiitis Bacteria Bacterial Infection Central Nervous System Cns Hospitals Parasite Genomics Genomic Medicine Outbreak

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