A new method uses synthetic introns to express therapeutic proteins selectively in cells bearing cancer-initiating mutations affecting RNA splicing factors, while healthy cells remain unaffected. This approach enabled the eradication of human leukemia, breast cancer and uveal melanoma cells in mouse models and significantly prolonged host survival.
The jellyfish-derived green fluorescent protein StayGold is bright and hardly fades, contributing to improving spatiotemporal resolution and dramatically extending the observation period. To fully benefit from the rich photon budget, we tried some unusual illumination modalities for sustainable, quantitative live-cell or volumetric imaging.
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