An international team led by researchers at the University of Toronto has found a family of natural compounds with potential as new and more effective treatments for parasitic worms. The compounds stall the unique metabolic process that worms use to survive in the human gut.
"This is the first time that we have been able to screen for drugs that specifically target the unusual metabolism of these parasites," said Andrew Fraser, principal investigator on the study and professor of molecular genetics at the Donnelly Centre and the Temerty Faculty of Medicine.to study RQ-dependent metabolism, and our collaboration with RIKEN, one of Japan's biggest research agencies.
"The study shows the power of the screening approach, allowing researchers in this case to search through a very large number of molecules within a focused collection of natural products. Screens are very efficient, which is key for addressing urgent research questions of global relevance like this one."
Medical Topics Alzheimer's Research Pharmaceuticals Pests And Parasites Biology Soil Types Microbiology
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