Nanoparticle asymmetry shapes an immune response

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The chirality, or handedness, of nanoparticles is shown to be a key factor in determining how well such particles engage with the immune system — a finding that might help to inform the design of vaccines and anticancer therapeutics.

Shape is all-important for molecules, especially when it comes to a property known as chirality .

A chiral molecule exists in two forms, called enantiomers, that are chemically identical, but are mirror images of each other, and that interact with other molecules in different ways. Chiral molecules have long been used in drug design — and some molecules can even be tailored to interact with the body in enantiomer-specific ways.

 

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