"we were very surprised to learn that no matter which type of cell we studied there were prominent changes" compared with brain tissue samples from controls who died of other causes, said Wyss-Coray.
The changes in the COVID-19 brains showed signatures of inflammation, abnormal nerve cell communication, and chronic neurodegeneration. "Across cell types, COVID-19 perturbations overlap with those in chronic brain disorders and reside in genetic variants associated with cognition, schizophrenia, and"Viral infection appears to trigger inflammatory responses throughout the body that may cause inflammatory signaling across the blood–brain barrier, which in turn could 'trip off' neuroinflammation in the brain," Wyss-Coray said., and other neurological and psychiatric symptoms of long COVID.
"While we studied only brains from people who died of COVID-19, we believe it is likely that similar, but hopefully weaker, signs of inflammation and chronic neurodegeneration will be found in COVID-19 survivors, especially those with chronic brain symptoms," Wyss-Coray said.
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