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Swellness: Turns out, even in the animal kingdom, females are considered too hormonal to take seriously in drug trials

Photo-Illustration: The Cut. Photo: JacobStudio/Getty Images/iStockphoto Today in gender biases you didn’t know existed: Many drug trials on mice and rats are conducted only on males of the species. Historically, researchers have claimed that the short reproductive cycles of female rodents could throw off the reliability of their findings. Yes, even in the animal kingdom, females are considered too hormonal to take seriously.

“Some researchers would say that because one day the animals have high levels of estrogen and the next day they have low levels of estrogen, you couldn’t possibly understand anything about the brain or physiology or the effects of the drug in a drug trial,” she added. But of course, males of any species, be they mice or men, have hormones too. “Male mice and rats [also] have lots of fluctuating hormones, but there’s such a myopic focus on female hormones,” said Dr. Shansky.

 

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