Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation

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Intracellular complement signaling in human and mouse macrophages controls inflammatory response in atherosclerosis models, a new SciImmunology study reports.

We thank the healthy volunteers and the patients for support. We thank L. Ryan and A. Marstad for initial contribution to the plaque analysis and L. Hoang for Immunogold staining.

Data related to the gene arrays performed using the carotid plaques from patients with atherosclerosis are deposited in GEO under accession number GSE162389. Data related to the gene arrays performed using monocytes isolated from the kidneys of mice after FA-induced KI are deposited in GEO under accession number GSE186545. The cell-permeable factor B inhibitor is available from GSK under a cooperative research and development agreement with the university/institution.

 

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