, a low-carbohydrate diet or a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols plus traditional IBS dietary advice outperformed pharmacological treatment.
The participants were assigned 1:1:1 to receive a low-FODMAP diet plus traditional dietary advice , a fiber-optimized diet with low carbohydrates and high protein and fat , or optimized medical treatment based on predominant IBS symptoms. Participants were masked to the names of the diets, but the pharmacological treatment was open-label.
A stricter score reduction of ≥ 100 points was observed in 61% of the low-FODMAP group, 58% of the low-carbohydrate group, and 39% of the optimized medical treatment group. The authors noted that since all three treatment options showed significant and clinically meaningful efficacy, patient preference, ease of implementation, compliance, cost-effectiveness, and long-term effects, including those on nutritional status and gut microbiota, should be considered in personalized plans.Nybacka and colleagues recommended additional trials before implementing the low-carbohydrate diet in clinical practice.
"However, there are problems with the low-FODMAP diet, as it can be difficult to institute, it can be fairly restrictive, and long-term use has the potential to lead to micronutrient deficiencies," he said."Importantly, large studies comparing dietary interventions directly to medical therapies are absent, which led to the study by Nybacka and colleagues."
Source: Healthcare Press (healthcarepress.net)
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