"Here we show that oxytocin, a neuropeptide also known as the love hormone, is capable of activating heart repair mechanisms in injured hearts in zebrafish and human cell cultures, opening the door to potential new therapies for heart regeneration in humans," said Dr. Aitor Aguirre, an assistant professor at the Department of Biomedical Engineering of Michigan State University, and the study's senior author.Cardiomyocytes typically die off in great numbers after a heart attack.
"Think of the EpiPCs as the stonemasons that repaired cathedrals in Europe in the Middle Ages," explained Aguirre. Unfortunately for us, the production of EpiPCs is inefficient for heart regeneration in humans under natural conditions.Enter the zebrafish: famous for their extraordinary capacity for regenerating organs, including the brain, retina, internal organs, bone, and skin. They don't suffer heart attacks, but its many predators are happy to take a bite out of any organ, including the heart—so zebrafish can regrow their heart when as much as a quarter of it has been lost.
FrontiersIn : 'oxytocin has... unsuspected function: It stimulates stem cells derived from the heart's outer layer (epicardium) to migrate ..and..develop into cardiomyocytes, muscle cells that generate heart contractions..could one day be used to promote the regeneration of the human heart'
FrontiersIn Love is always the best medicine ♥️
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