Insights into how the brain discriminates between wanting to eat vs. liking to eat.

Aberrant control of pleasure center activity could underlie the development of maladaptive eating behavior.

We humans enjoy many things—especially eating. Yet sometimes, our relationship with food becomes quite distorted. A recent study investigated the interaction between our brain’s endogenous cannabinoid system and our brain’s reward system and how this interaction might underlie the altered eating habits of people with anorexia nervosa.activity within the brain’s principal reward center, the nucleus accumbens, with levels of the body’s two main endocannabinoids, AEA and 2-AG.

The study further discovered that AEA and 2-AG may play distinct and independent roles in regulating BMI by influencing how we experience the pleasure of eating. Their findings indicated that an increase in AEA concentrations promoted weight gain, while an increase in 2-AG tended to counteract the weight gain. In both healthy control subjects of those with anorexia nervosa, BMI is distinctly regulated by circulating levels of AEA and 2-AG.

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