If at First Tirzepatide Doesn't Succeed, Keep Trying

from Lilly's SURMOUNT-1 trial of people with overweight or obesity but not diabetes suggest that the drug will almost always produce at least 5% weight loss eventually, even among slow responders.

The analysis showed that among participants who had lost less than 5% of their body weight by week 12 of tirzepatide, nearly all went on to lose 5% or more by week 72. Thus, Gudzune said,"It is reasonable to consider treatment for longer than 12 weeks to determine weight loss response to tirzepatide, which takes at least 20 weeks to reach the highest dose."

The current post hoc analysis included a total of 1545 patients who had been randomly assigned to total tirzepatide doses of 5 mg, 10 mg, or 15 mg, and had data available at weeks 0, 12, 24, and 72. Among those, 1267 had lost at least 5% of their body weight by week 12, defined as"early responders," and 278 had lost less than 5% of body weight by then, called"slow responders."

Even in the group maintained on the lowest 5-mg dose throughout the trial, 87% had achieved at least 5% weight loss by week 72, with 15% achieving at least 15%. And in the group that had been titrated up to 15-mg tirzepatide, 94% of slow responders achieved at least 5% weight loss. "Future studies are warranted to better understand the variability in weight loss response to tirzepatide treatment," Gudzune concluded.

Source: Healthcare Press (healthcarepress.net)

Obese Weight Management Weight Loss Treatment Guidelines Clinical Guidelines Guidelines Washington DC Washington - District Of Columbia Maryland Washington Body Mass Index BMI Endocrinology Endocrine System Prediabetes Borderline Diabetes Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D

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