IBS Relief: Common Drug Improves Symptoms of Irritable Bowel Syndrome

A cheap and widely available prescription drug can improve symptoms of irritable bowel syndrome in patients seen in GP surgeries, new research has found. The study was recently presented at UEG Week 2023, a conference by the European Society of Gastrointestinal Endoscopy.Amitriptyline, which is commonly used at low doses for a range of health concerns, has been found to improve irritable bowel syndrome symptoms too, according to the results of the ATLANTIS trial.

Amitriptyline belongs to a group of medications called tricyclics. Originally used at high doses to treat depression, today these are rarely used for this condition because newer treatments have been developed. Co-chief Investigator Hazel Everitt, Professor of Primary Care Research at the Primary Care Research Centre, University of Southampton, said: “Prior to ATLANTIS, GPs haven’t often prescribed amitriptyline for IBS as the research evidence was uncertain, but our new research provides good evidence of benefit.

Participants taking amitriptyline reported a bigger improvement in their symptom scores after six months compared with those taking a placebo. Those taking amitriptyline were almost twice as likely as those taking a placebo to report an overall improvement in IBS symptoms, with amitriptyline performing better across a wide range of IBS symptom measures.

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