While antibody response is only one part of vaccine-induced protection, Dr. Segev’s group also examined the in their population of immunosuppressed patients.
Though the study only measured antibody response, Dr. Segev believes the results will be reasonably representative for clinical outcomes. “Definitely, with a third dose, one can increase the immune response, and the underlying biological framework is that increasing the antibody response will also increase the clinical protection,” he explains.
Based on these and other research findings, on August 12 the U.S. Food and Drug Administration authorized a third dose of vaccine for certain immunocompromised individuals. This applies primarily to solid organ transplant recipients or those who are diagnosed with conditions “that are considered to have an equivalent level of immunocompromise.
4. There’s also interest in potentially mixing and matching types of vaccines for a better immune response.
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