How Can Kidney Cancer Patients Benefit From New Combination Therapy?

The latest research supports immune checkpoint inhibitor therapy for clear cell and non–clear cell renal cell carcinoma , but patient selection is key to optimize outcomes, according to a medical oncologist from the Dana-Farber Cancer Institute, Boston.

For patients with metastatic clear cell renal cell carcinoma, the IMDC and MSKCC prognostic models stratify patients to favorable, intermediate, and poor risk groups based on clinical and lab factors. The IMDC risk stratification model is used as a prognostic model to stratify patients diagnosed with metastatic kidney cancer, Dr Serzan said.approved pembrolizumab

Several similar studies of adjuvant immune checkpoint inhibitors for renal cell carcinoma involving atezolizumab vs placebo, nivolumab plus ipilimumab vs placebo, and nivolumab vs observation have not shown significant benefits in terms of disease-free survival, Dr Serzan noted.), which were updated this year, support the use of adjuvant pembrolizumab for patients with stage II, III, or IV clear cell renal cell carcinoma after partial or radical nephrectomy, he said.

The median progression-free survival was 12.4 months in the combination group vs 8.5 months in the sunitinib group for patients at intermediate or poor risk of recurrence. The median progression-free survival was significantly greater in sunitinib patients with favorable risk vs combination patients with favorable risk .

However, cons of this treatment include lack of data on treatment-free survival as well as the decrease in progression-free survival and overall survival hazard ratios over time and potential chronic VEGF/TKI toxicities, he said.

For patients not eligible for ICIs because of uncontrolled autoimmune disease, or high-dose glucocorticoids, Dr Serzan recommended treatment with cabozantinib, lenvatinib/everolimus, pazopanib, or sunitinib.

Source: Healthcare Press (healthcarepress.net)

Renal Cell Cancer RCC - Renal Cell Carcinoma Cancer Of The Kidney Renal Cell Carcinoma RCC Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Metastasis Metastatic Carcinoma Metastatic Cancer Metastases Biologic Therapy Biologics Kidney Cancer Renal Cancer Antineoplastic Drug Anti-Cancer Agents Erlotinib Gefitinib Imatinib Rituximab Su11248

United States Latest News, United States Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Gospel singer undergoes lifesaving kidney transplant after losing mom, 2 sisters who battled chronic kidney diseaseTammy Edwards said of her survival, 'The good news had to come our way.'
Source: ABC - 🏆 471. / 51 Read more »

Community rallies around Eight Mile woman battling kidney cancerThe Prichard community gathered Saturday at The Barn bar for a benefit for an Eight Mile woman battling stage IV kidney cancer.
Source: FOX10News - 🏆 581. / 51 Read more »

Scientists develop novel antibody treatment for kidney cancerScientists have built upon BTE technology to develop new and improved recombinant and synthetic DNA versions of therapeutic antibodies that target CA9, called Persistent Multivalent T Cell Engager (CA9-PMTE), that shows promise in pre-clinical models as a potent, long-lasting treatment against ccRCC.
Source: ScienceDaily - 🏆 452. / 53 Read more »

Françoise Hardy, renowned French singer-songwriter, has died at 80Hardy was diagnosed with lymphatic cancer in 2004, and also had laryngeal cancer.
Source: NPR - 🏆 96. / 63 Read more »

Immunotherapy to treat cancer gave rise to 2nd cancer in extremely rare caseMiriam Bergeret is a science writer and editor based in Toronto, Canada. Miriam holds a master's degree in laboratory medicine and pathobiology from the University of Toronto, where she also studied science journalism and communication.
Source: LiveScience - 🏆 538. / 51 Read more »

Cancer’s Molecular Achilles Heel: Key to Improving Cancer Treatments DiscoveredScience, Space and Technology News 2024
Source: SciTechDaily1 - 🏆 84. / 68 Read more »