Holy Cross vs Iowa Predictions, Picks, and Odds: Caitlin Clark's Title Quest Begins

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March Madness picks, odds, and predictions for Holy Cross Crusaders vs Iowa Hawkeyes. March Madness free picks and best bet analysis.

Caitlin Clark and Iowa begin their run to an NCAA championship on Saturday against Holy Cross. Our women's March Madness picks break down the best bets as the game's best player aims to keep making history.Big Ten tourney champ and No. 1 seed Iowa Hawkeyes have some unfinished business when they meet No. 16 seed Holy Cross Crusaders in their opening tilt of the 2024 Women’s March Madness campaign.

Of course, Iowa would be heavily favored — it’s won seven of its last eight, has one loss at Carver-Hawkeye Arena and averages 92.8 per tilt. The Hawkeyes exceeded that average in seven of their last eight, and Clark is a major reason why. The Lady Crusaders allow the 21st-fewest points nationally with the 10th-best 3-point defense — it’s allowed 69 or fewer points in their last five and might make things difficult for the scoring leader.

One record she hasn’t broken yet — and would need a couple of big shooting nights to do so — is the 537-career made three pointers mark set in 2023 by Oklahoma Sooners guard Taylor Robertson. The Crusaders defense won’t make it easy on Clark — they boast one of the best 3-point defenses nationally. Ponytail Pete has struggled from beyond the arc over her previous five at Carver-Hawkeye, but this is a game on the national stage, and I expect her to be in launch mode while chasing this last record.

The Hawkeyes are a team that purely outscores their opponents because their defense is non-existent. Their 71.9 points allowed is No. 314 nationally and Holy Cross can score the basketball — FanDuel has the best number for the Crusaders but you will pay -114 for this market.

 

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