High-Dose Valproate Linked to Significant Weight Gain

High-dose valproate is associated with weight gain in psychiatric patients, with the greatest gain reported in those taking ≥ 1300 mg/d, new data showed.The researchers used 1-year data from two longitudinal studies conducted between 2007 and 2022.

The researchers used linear mixed-effect models and logistic regressions to analyze the association between doses of valproate and metabolic outcomes.=.02). The greatest weight gain was observed in patients receiving doses ≥ 1300 mg/d, with a 0.50% increase in weight for each dose increment of 500 mg (In men, each 500-mg dose was associated with an increase of 0.59%, while the trend in women was for an increase of 0.40% (The researchers did not find associations between valproate doses and blood glucose, lipid levels, or blood pressure across a treatment period of 6 months.

Weight Gain Weight Management Blood Adherence Adherence To Medication Issues For Patients Compliance Drug Compliance Treatment Adherence Bipolar Disorder Bipolar Mania Manic Depression Bipolar Affective Disorder Mental Region Exercise Physical Activity Geriatrics Elder Care Geriatric Medicine Older Adults Seniors Senior Citizens Elderly Hospitals Lipids

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