HHS Explores Lung-on-a-Chip Technology in Developing Chemical Injury Treatments

The Biomedical Advanced Research and Development Authority , part of the HHS Office of the Assistant Secretary for Preparedness and Response, will provide technical expertise and approximately $13.5 million over the next two years to Wake Forest Institute for Regenerative Medicine of Winston-Salem, North Carolina, to validate how the group’s lung-on-a-chip technology, also known as an organ tissue equivalent, works in modeling the effects of chlorine gas on human lungs.

The lung-on-a-chip platform is part of WFIRM’s overall Body-on-a-Chip program, a miniaturized system of human organs that can be used to model the body’s response to harmful agents. To create the system, human cells are used to create tiny 3D organ-like structures called tissue equivalents that mimic the function of the heart, liver, lung, or blood vessels.

Scientists’ observations on the effects of chlorine gas on human lungs is limited to accidents and chemical warfare incidents, both of which are uncommon. Although animal models are available and well-studied, these may not accurately reflect the human response and can be expensive to use. WFIRM’s study will determine whether the lung-on-a-chip reacts similarly to the way human lungs respond, and will expand the scientific understanding of lung injuries from inhaled chlorine.

Depending on the outcome of these early studies, BARDA and its partners may use organ-on-a-chip technology to test potential treatments for lung or other organ injuries that are caused by other chemical, biological, radiological, or nuclear agents.

Source: Healthcare Press (healthcarepress.net)

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