Disclosure: Morie A. Gertz, MD, has disclosed the following relevant financial relationships:is a condition marked by the accumulation of insoluble beta-sheet fibrillar protein aggregates in tissues that can be acquired or hereditary.and retinol-binding protein and is primarily synthesized in the liver, becoming unstable as a result of the pathogenic mutations.
in Portugal, Brazil, Sweden, and Japan and alongside smaller foci in regions, such as Cyprus and Majorca. This disease's variable incidence across Europe is now perceived to be. It is attributed to heightened disease awareness among healthcare providers and the broader availability of genetic testing, extending its recognized impact to atin the disease's transmission, with autosomal-dominant inheritance patterns and high penetrance among carriers of pathogenic mutations.
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