So what are the ideal conditions for using pooled testing? The success of pooled testing depends on a number of different factors.
If an infectious disease like COVID-19 is a forest fire, says Pilcher, then the U.S and most of the world is still in the urgent fire-fighting stage, testing as widely as possible and isolating cases when they’re found. Once the raging fire is contained, there are still embers and smoldering fires that need to be detected and doused.
By comparison, people with HIV often have very high viral loads even early in the infection, says Dr. Jennifer Rakeman, assistant commissioner and lab director for the New York City Public Health Laboratories, which are part of the New York City Department of Health and Mental Hygiene. So even when samples are pooled together, there’s enough of detectable virus for the tests to pick it up. In the New York labs, 16 HIV samples are generally diluted into a single pooled sample.
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