Hepatitis E Vaccine Shows Long-Term Efficacy

. Molecular studies of HEV strains have identified four main genotypes. Genotypes 1 and 2 are limited to humans and are transmitted through contaminated water in resource-limited countries, mainly in Asia. Genotypes 3 and 4 are zoonotic, causing sporadic indigenous hepatitis E in nearly all countries.

Follow-up occurred every 3 months. Participants with hepatitis symptoms for 3 days or more underwent alanine aminotransferase concentration measurement. Patients with ALT concentrations ≥ 2.5 times the upper limit of normal were considered to have acute hepatitis.

In the subgroups evaluated for immunogenicity persistence, among those who were initially seronegative and received three doses of hepatitis E vaccine, 254 out of 291 vaccinated participants in Qingdao after 8.5 years and 1270 out of 1740 vaccinated participants in Anfeng after 7.5 years maintained detectable antibody concentrations.

Vaccines Hepatitis E Adult Vaccines Hepatitis Viral Hepatitis Hepatitis A Immunizations Vaccination Igg Immunoglobulin G Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology Medical Technology Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial Double-Blind Study

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