Glaxo Says Its Covid-19 Antibody Drug Works Against Omicron

GlaxoSmithKline said its antibody treatment retained effectiveness against the Omicron variant in laboratory studies, even as early data suggests that similar treatments work less well against the strain

Biotechnology, Pharmaceuticals

12/8/2021 12:40:00 AM

GlaxoSmithKline said its antibody treatment retained effectiveness against the Omicron variant in laboratory studies, even as early data suggests that similar treatments work less well against the strain

GlaxoSmithKline and Vir said their Covid-19 antibody treatment retained effectiveness against the Omicron variant in laboratory studies, even as early data suggests that similar treatments work less well against the strain.

said their Covid-19 antibody treatment retained effectiveness against the Omicron variant in laboratory studies, even as early data suggests that similar treatments work less well against the highly mutated strain.The results provide hope that at least one monoclonal antibody therapy—a form of treatment that has proven useful in blunting severe disease—will remain effective against Omicron, which has been

detected in dozens of countriesincluding the U.S. since it was identified by scientists in South Africa two weeks ago.“We are confident that sotrovimab will continue to provide significant benefit for the early treatment of patients hoping to avoid the most severe consequences of Covid-19,” said George Scangos, chief executive of Vir, in a statement. He added that sotrovimab was slightly weakened by Omicron, but that the difference wasn’t significant.

The result confirmsearlier laboratory datasuggesting that the drug worked against the variant. That data, published last week, showed that sotrovimab maintained activity against several of Omicron’s key mutations. Researchers at the companies confirmed the findings, which haven’t been peer reviewed, by testing the drug against the whole spike of Omicron. They did that by building a so-called pseudovirus—meaning they recreated the whole spike protein of Omicron on a different virus—and worked over the weekend to test sotrovimab against it, said Amanda Peppercorn, who leads Covid-19 monoclonal antibody development at Glaxo. headtopics.com

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The companies are also working with public-health laboratories to test sotrovimab against the whole live virus. For other variants, tests against the spike alone have reliably predicted the results against the whole virus, according to Dr. Peppercorn.

Omicron, which has around 50 mutations—an unusually high number—appears to spread more quickly than other strains, but there are early signs from a study in South Africa that itmay cause milder illness. Scientists are testing whether it renders existing vaccines less effective.

Scientists and vaccine makers are investigating Omicron, a Covid-19 variant with around 50 mutations, that has been detected in many countries after spreading in southern Africa. Here’s what we know as the U.S. and others implement travel restrictions. Photo: Fazry Ismail/EPA-EFE/Shutterstock

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Monoclonal antibodies mimic a part of the body’s immune response to the virus and are typically used at an early stage of infection to reduce the risk of serious illness. In a large clinical trial, sotrovimab reduced the risk of hospitalization or death by 79% in people with mild or moderate Covid-19 at high risk of progressing to severe disease. headtopics.com

Monoclonal antibody treatments target parts of the spike protein, where most of Omicron’s mutations lie, leading to concerns that these drugs could prove less effective against the new variant.

Read more: WSJ Health »

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Small-Cap Stocks Hit Hard by Covid-19 Omicron VariantThe Russell 2000 benchmark has dropped 7.4% since Thanksgiving, when the fast-spreading new variant made headlines. Last week, the index fell into a correction, declining more than 10% from its November record. 당신이 세상을 사랑한다면 천국은 저절로 싫어하게 될 것입니다 OurWayToMenengai4 Hit hard because of a BS variant. You mean quantitative easing is about to f*** you and no one is hear to hear you cry wolf anymore?

COVID-19 Live Updates: Omicron cases in U.S. 'likely to rise', CDC warnsThe CDC is warning that Omicron cases are 'likely to rise' across the U.S. as the variant spreads to over a dozen states and over 40 countries. Follow Newsweek's liveblog for all the latest. Early indications are that Omicron is highly infectious, but not YET as severe as earlier variants. Just get vaccinated!!! It’s strange that there is a spread but we aren’t totally sure how or what symptoms this variant has! Anyways caution is the word. Get vaccinated and wear your mask

Here’s How Covid-19 Vaccine Makers Plan To Tackle OmicronI am a London-based reporter for Forbes covering breaking news. Previously, I have worked as a reporter for a specialist legal publication covering big data and as a freelance journalist and policy analyst covering science, tech and health. I have a master’s degree in Biological Natural Sciences and a master’s degree in the History and Philosophy of Science from the University of Cambridge. Follow me on Twitter theroberthart or email me at rhartforbes.com No go9d the vaccine with RNAm for atletic!because dont' t are true and save peolple! Can you explain this

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