said their Covid-19 antibody treatment retained effectiveness against the Omicron variant in laboratory studies, even as early data suggests that similar treatments work less well against the highly mutated strain.
“We are confident that sotrovimab will continue to provide significant benefit for the early treatment of patients hoping to avoid the most severe consequences of Covid-19,” said George Scangos, chief executive of Vir, in a statement. He added that sotrovimab was slightly weakened by Omicron, but that the difference wasn’t significant.suggesting that the drug worked against the variant.
Omicron, which has around 50 mutations—an unusually high number—appears to spread more quickly than other strains, but there are early signs from a study in South Africa that it. Scientists are testing whether it renders existing vaccines less effective. Monoclonal antibodies mimic a part of the body’s immune response to the virus and are typically used at an early stage of infection to reduce the risk of serious illness. In a large clinical trial, sotrovimab reduced the risk of hospitalization or death by 79% in people with mild or moderate Covid-19 at high risk of progressing to severe disease.
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