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Genetic Testing Rates Low in Metastatic Castration-Resistant Prostate Cancer

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Prostate Carcinoma News

Malignant Prostate Neoplasm,Prostate Cancer,Cancer Of The Prostate

Most men with mCRPC in the United States do not receive recommended genetic testing for relevant mutations, suggesting efforts are needed to address barriers to testing.

A minority of patients with metastatic castration-resistant prostate cancer in the United States undergo genetic testing for homologous recombination repair mutations, despite the potential prognostic and predictive value of these mutations for therapies like poly polymerase inhibitors, research shows.HRR gene mutations are found in approximately 25%-30% of patients with mCRPC.

The authors assessed the use of HRR mutation genetic testing, including next-generation sequencing — specifically any somatic HRR, tissue, or circulating tumor DNA test — or a somatic or germlineThe researchers then determined the timing of HRR testing relative to mCRPC diagnosis and initiation of first-line therapy and identified factors associated with HRR testing.Overall, 37.7% of patients received HRR testing; the majority did not. The proportion of patients tested peaked in 2020 at 55.

Source: Healthcare Press (healthcarepress.net)

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