French Cohort Shows Good Prognosis of MSI Colorectal Cancer

Receive email when new articles are published onA French prospective real-life cohort confirmed the favorable prognosis of nonmetastatic microsatellite instability colorectal cancers. These cancers nevertheless entailed a high risk for recurrence in stage III, especially when not treated with adjuvant chemotherapy. The initial follow-up results of the cohort were presented at the French-speaking Days of Hepato-Gastroenterology and Digestive Oncology.

The dMMR-MSI nonmetastatic colorectal cancers are associated with a better prognosis but resistance to adjuvant 5-fluorouracil-based treatment in stage II. However, in metastatic situations, the dMMR-MSI status is associated with a poor prognosis but major effectiveness with checkpoint inhibitor immunotherapy.

The average age of included patients was around 70 years. Women are in the majority , which is expected for this type of cancer, said Tougeron. In 41% of cases, Lynch syndrome was confirmed. Patients with the syndrome were younger, while sporadic forms were more common in older patients.

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