A new study reveals a potential treatment strategy for neurodegenerative diseases by targeting astrocytes with drugs that inhibit HDAC3, protecting nerve cells and offering hope for advancements in therapies for conditions such as Alzheimer’s and Parkinson’s. Credit: SciTechDaily.
The researchers created a new cellular technique to test thousands of possible medications for their ability to prevent these rogue astrocytes from forming.Innovations in Drug Screening and Therapeutic Potential They found that blocking the activity of a particular protein, HDAC3, may prevent the development of dangerous astrocytes. The scientists discovered that by administering medications that specifically target HDAC3, they were able to prevent the development of dangerous astrocytes and significantly increase the survival of nerve cells in mouse models.
“Therapies for neurodegenerative disease typically target the nerve cells directly,” Tesar said, “but here we asked if fixing the damaging effects of astrocytes could provide therapeutic benefit. Our findings redefine the landscape of neurodegenerative disease treatment and open the door to a new era of astrocyte targeting medicines.”
Source: Tech Daily Report (techdailyreport.net)
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