vaccines and then randomly assigned to get a booster dose of one of the three, about four to six months later.
In general, people who received a booster of a vaccine that was different from the one they originally received saw antibody increases that were similar to or higher than in those who had received another dose of the same vaccine of their initial shot. There were small differences, however.
The J&J shot uses an adenovirus vector to deliver viral genes to the immune system, which then recognizes them as foreign and mounts an attack, while Pfizer-BioNTech’s and Moderna’s vaccines utilize a new technology of delivering the mRNA form of SARS-CoV-2’s genetic material directly.
The findings are encouraging because they suggest that it’s safe for providers to mix and match doses when it comes to boosters. Public health experts have advocated that everyone who has been immunized against COVID-19 get a booster shot to combat waning protection from the vaccines in the face of the faster-spreading Delta variant, and the ability to get any of the three vaccines will ensure that more people will get the additional shot.
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