The menthyl esters showed exceptional anti-inflammatory and anti-obesity activities during preclinical studies and can be developed as therapeutic compounds with further research.
In a recent study, a team of researchers led by Professor Gen-ichiro Arimura from the Department of Biological Science and Technology, Tokyo University of Science, Japan, developed and investigated menthyl esters of valine and isoleucine , which are derived from menthol by replacing its hydroxyl group with valine and isoleucine, respectively.
Elated with their findings, the researchers went a step further and investigated the mechanism of action of the menthyl esters. They discovered that liver X receptor -- an intracellular nuclear receptor, had an important role in the anti-inflammatory effects and this was independent of the cold-sensitive transient receptor TRPM8, which primarily detects menthol.
"Although this study focused on their functions and mechanisms of action in diseases modeled after inflammation and obesity, we expect that these compounds will also be effective against a wide range of lifestyle-related diseases caused by metabolic syndrome, such as diabetes and hypertension, as well as allergic symptoms," says Prof. Arimura optimistically.
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