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Father's gut microbes affect the next generation

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Researchers changed the composition of the gut microbiota in male mice through common antibiotics, inducing a condition called dysbiosis, and found that: - Mouse pups sired by a dysbiotic father show significantly lower birth weight, and have increased risk of growth disorders and postnatal mortality.

The gut microbiota is the microbial community that occupies the gastrointestinal tract. It is responsible for producing enzymes, metabolites, and other molecules crucial for host metabolism and in response to the environment.

The scientists then analysed changes in the composition of important testicular metabolites. They found that in male mice dysbiosis affects the physiology of the testes, as well as metabolite composition and hormonal signalling. At least part of this effect was mediated by changes in the levels of the key hormone leptin in blood and testes of males with induced dysbiosis.

"We have observed that intergenerational effects disappear once a normal microbiota is restored. That means that any alteration to the gut microbiota able to cause intergenerational effects could be prevented in prospective fathers" said Peer Bork, EMBL Heidelberg Director, who participated in the study.

Source: Entertainment Trends (entertainmenttrends.net)

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