The season begins with perhaps the most anticipated season opener in some time, as the Buffalo Bills take on the defending Super Bowl champion Los Angeles Rams in SoFi Stadium on Thursday, Sept. 8.The Bills, of course, are the odds-on favorite to win the AFC West and challenge for Super Bowl 57, entering the season at +550 to hoist the Lombardi Trophy. The Rams aren’t too far behind, however, and sit at +1200 to repeat.
This season, Baltimore opens on the road at the New York Jets where the Ravens are a 7-point favorite.The three biggest point spreads in Week 1, according to DraftKings, are with teams breaking in new quarterbacks The second biggest spread is for the San Francisco 49ers, who are 7-point favorites over the Chicago Bears with Trey Lance making his debut for the West Coast team.
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