Jones and her colleagues tested a similar approach on younger children to see if their immune systems could be changed if treated at an earlier age. She helped lead a study for the current treatment, Aimmune Therapeutics’ Palforzia, and has consulted for the company.
The new government-funded study involved 146 children in the U.S. ages 1 to 3. They were given daily doses of peanut powder mixed in food or a dummy powder — oat flour. When the treatment ended, 71% of those who got the peanut powder could tolerate the equivalent of 16 peanuts. Six months later, 21% still could. In the dummy powder comparison group, 2% could tolerate 16 peanuts at the end of the treatment and six months later.
The research “really supports something that we thought for a while in the field,” said Dr. Joyce Hsu, an allergy specialist at Brigham and Women’s Hospital in Boston who was not involved in the study. “Children’s immune systems are generally more malleable when they are younger.”Hsu’s clinic offers an allergy treatment with peanut protein for children ages 4 months and older.
In the study, toddlers with peanut allergies were given increasing amounts of peanut powder daily to build their tolerance. After 2 1/2 years, close to three-quarters were able to tolerate the equivalent of about 16 peanuts.
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