Doctor treating COVID-19 patients gambles on clot-busting drug

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Doctors caring for the sickest COVID-19 patients are trying new ways to attack the coronavirus. One theory is that they have blood clots in their lungs.

The woman was dying. Workers at New York’s Mt. Sinai Hospital were about to call her husband and break the news that there was nothing left to try. Then Dr. Hooman Poor took a gamble.

Already, many hospitals are attempting preventive doses of blood thinners to keep clots from forming. There’s huge debate over what kind to try, what dose is safe — the drugs can cause dangerous bleeding — and how soon to start. Story continuesTwenty minutes after the injection of tPA, her oxygen levels rose. Poor was elated. But not for long.

But last weekend, Poor's team tested the new clot-fighting approach in four other severely ill patients. One didn’t survive, dying of cardiac arrest from a massive blood clot in his heart. Pugliese called Poor’s tPA report “very intriguing” and concluded: “What these doctors did in these very ill patients who were dying was a judgment call, and it was the right thing to do.”

 

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