The primary endpoint was the pathologic cancer stage at the time of diagnosis. Early-stage cancer was defined as either dysplasia or pathologic stage 0/I cancer, and advanced-stage cancer was defined as pathologic stage II/III/IV cancer.The researchers say the higher percentage of advanced cancer in patients with CD rather than in patients with UC may suggest that regular surveillance was not effective for patients with CD or that physicians were less adherent to surveillance intervals.
In multivariate analysis that was adjusted for age, diagnosis year, regular surveillance, and histologic type in UC, biologics and 5-ASA were significantly associated with a lower risk of advanced-stage cancer."These results indicate that biologics and 5-ASA are drugs that are potentially associated with a lower risk of advanced cancer in patients with UC but not with CD," Seishima and colleagues say.
"By focusing only on those who have been diagnosed with cancer, one cannot actually conclude what the risk of cancer is and if these medications reduce the risk ofPatients undergoing treatment with biologics likely receive closer follow-up, so in these patients, cancers are less likely to be diagnosed at an advanced stage, said Ananthakrishnan. For that reason, the study can't clearly establish the degree to which the effect was due to medication or surveillance, he added.
Source: Healthcare Press (healthcarepress.net)
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