A healthcare worker prepares a syringe with a dose of the Pfizer-BioNTech coronavirus disease vaccine at the Newcastle Racecourse vaccination centre, in Newcastle upon Tyne, Britain January 29, 2021. REUTERS/Lee Smith/File PhotoCOVID-19 vaccine generates antibody responses three-and-a-half times larger in older people when a second dose is delayed to 12 weeks after the first, a British study said.
After Britain moved to extend the interval between doses, Pfizer and vaccine partner BioNTech said there was no data to back up the move. However, Pfizer has said that public health considerations outside of the clinical trials might be taken into consideration.
The study, which has not yet been peer-reviewed, looked at 175 people aged between 80 and 99, and found that extending the second dose interval to 12 weeks increased the peak antibody response 3.5-fold compared to those who had it at three weeks.
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