Researchers from the Australian Regenerative Medicine Institute at Monash University have discovered that as organisms, including humans, age, their muscles revert to an “early-life” state, potentially prolonging life.
According to Professor Currie, “…there is a pressing need to understand the mechanisms that drive sarcopenia so that we can identify and implement suitable medical interventions to promote healthy muscle aging,” he said.has recently emerged as a new model for the study of aging. Killifish have the shortest known life span of any vertebratethat can be bred in captivity.
“In this study, we performed a thorough cellular and molecular characterization of skeletal muscle from early life, aged and extremely old late-life stages, revealing many similarities to sarcopenia in humans and other mammals,” she said. To better understand the mechanisms behind this, the research team surveyed the metabolism of fish at different stages of the aging process. This experiment surprisingly revealed that certain features of the metabolism of the very oldest fish actually were rejuvenated to resemble those of young fish. It highlighted the critical role of lipid metabolism in this process of rejuvenation.
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