Individuals with Down syndrome have a dysregulated immune system, which is associated with increased risk of autoimmunity and poorer immune responses to infections and vaccines. Here, Lambert. used deep immune phenotyping to better understand the specific features that are associated with this dysregulation.
Here, we performed deep immunophenotyping of a cohort of individuals with Down syndrome across the life span, selecting for autoimmunity-free individuals. We simultaneously interrogated age- and sex-matched healthy controls and people with type 1 diabetes as a representative autoimmune disease. We built an analytical software, IMPACD , that enabled us to rapidly identify many features of immune dysregulation in Down syndrome shared with other autoimmune diseases.
ScienceTM Eating a poor diet that increases insulin resistance increases the risk for people with Down syndrome. Eating a regenerative diet improves anybody's life to be metabolically healthy insulin sensitive Regenerative soil regenerative food creates a life of ease ConsciousPlanet
ScienceTM My son ,now 24, has (please use the correct term) 'Down's Syndrome' (not DOWN) and has an autoimmune disease. However, so do/did myself (duel RA & PA as well as signs of Lupis) and his great grandfather (ALS). Going to be hard to trace autoimmune with trisomy not being inherited.
ScienceTM Oh
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