. It is a natural response of the human body cells to develop an immune memory for rapid action against an infection that also affected a person in the past.for other infections, including COVID, but this is the first time it has been noticed in the case of HIV. The current study reveals that immunologic memory in HIV patients is the root cause of prolonged inflammation. In order to prove the same, they performedThey cultured some immune cells in the lab and then divided them into two groups.
On the other side, the immune cells that weren't subjected to Nef didn't express any such behavior. These findings confirm immunologic memory resulting from HIV infection and its role in inflammation. "While this 'trained immunity' evolved as a beneficial immune process to protect against new infections, in certain cases, it may lead to pathological outcomes.
The authors point out that the main limitation of this research work is that it was done on human cells and mice, so the results need to be verified in real-life human infection.
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